Advances in medicinal research on tetrodotoxin
10.12206/j.issn.2097-2024.202207111
- VernacularTitle:河豚毒素的药用研究进展
- Author:
Qi WANG
1
;
Li FAN
1
;
Guangzhao LU
1
;
He ZHANG
1
;
Wen CAO
1
;
Ying LU
1
Author Information
1. Department of Pharmaceutical Science, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Keywords:
tetrodotoxin;
neurotoxin;
analgesic effect;
pharmacological activity;
preparation
- From:
Journal of Pharmaceutical Practice
2023;41(5):273-276
- CountryChina
- Language:Chinese
-
Abstract:
Tetrodotoxin (TTX) is a neurotoxin found in puffer fish and other marine organisms. It has been used as an inhibitor of voltage-gated sodium channels (VGSCs), which could selectively bind to the α-subunit on the outer vestibule of VGSCs, preventing sodium ions from entering the channel, resulting in pharmacological activities. As a typical sodium channel blocker, TTX shows a significant analgesic effect. TTX could selectively block Na+ channels without affecting other ion channels, therefore it could reduce the probability of adverse reactions caused by commonly used antiarrhythmic drugs. In addition, TTX has a significant role in detoxification and prevention of renal failure, so TTX has great potential as a medicine. The structure and physicochemical properties, mechanism of action, pharmacological activities and preparations of tetrodotoxin have been reviewed in this paper, so as to provide a general support for the evaluation of its druggability and application in the field of pharmacy.
