Progress on exosomes in the diagnosis and treatment of disease and drug delivery system
10.12206/j.issn.2097-2024.202207022
- VernacularTitle:外泌体用于疾病诊疗和药物递送的研究进展
- Author:
Hongbo WANG
1
;
Kangqing BIAN
1
;
Lingyi GUO
1
;
Yu DAI
1
;
Yuan YU
1
Author Information
1. Department of Pharmaceutical Science, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Keywords:
exosome;
targeted modification;
targeted therapy;
drug delivery
- From:
Journal of Pharmaceutical Practice
2023;41(5):265-272
- CountryChina
- Language:Chinese
-
Abstract:
As a type of extracellular vesicles, exosomes are released by living cells and contain diverse bioactive molecules, including nucleic acids, proteins, lipids and metabolites. They play an important role in various physiological and pathological processes by a special intercellular communication medium. As endogenous vesicles, exosomes also have the advantages of systemic circulation stability, good biocompatibility and specific targeting of tissues and cells, as well as they are promising candidates for drug delivery system. The production mechanism of exosomes describe was summarized, the methods of extraction and separation the application and mechanism of exosomes in immune and inflammation-related diseases, cardiovascular system diseases, nervous system diseases, tumors, etc. were reviewed. The engineering modifications of exosomes in high targeting properties based on the drug delivery were overviewed. Exosomes support the diagnosis and prognostic assessment of multiple diseases, which have broad application prospects as a very potential safe and specific endogenous nano-drug carrier.
