Research progress on relationship between N<sup>6</sup>-adenylate methylation modification and cell transformation and associated mechanism

VernacularTitle:N⁶-腺苷酸甲基化修饰与细胞转化关系及其机制的研究进展
Author: Zhao ZHAO ¹ ; Jingjing ZHENG ¹ ; Mingxuan YANG ¹ ; Suhua WANG ¹ ; Xuemin SHI ¹ ; Yuhang ZHAO ¹
Author Information

1. School of Public Health, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia 014040, China.
Publication Type:Review
Keywords: N6-adenylate methylation; epigenetic; tumor; epithelial-mesenchymal transition
From: Journal of Environmental and Occupational Medicine 2023;40(5):601-608
CountryChina
Language:Chinese
Abstract: As a reversible and dynamic epigenetic marker, N⁶-adenylate methylation (m⁶A) modification is the most common mRNA modification in eukaryotes. This paper briefly described how m⁶A can influence RNA splicing, stability, and translation after transcription, and then participate in a variety of signaling pathways and biological and pathological processes, regulating cell proliferation, apoptosis, epithelial mesenchymal transformation (EMT) processes, and tumor invasion and metastasis. In addition, according to current studies, m⁶A methyltransferases (writers) are believed to promote EMT and tumor development, and readers and erasers both promote and inhibit EMT in different research objects. In this review, we summarized the mechanism of m⁶A modification and its role in cell transformation, and pointed out the direction of disease treatment.