Research progress in epigenetic toxicity of diesel exhausts

VernacularTitle:柴油机尾气生物有害效应的表观遗传调控研究进展
Author: Xianan ZHANG ¹ ; Xiaobo LI ¹ ; Rui CHEN ¹
Author Information

1. a. Department of Health Toxicology and Health Chemistry b. Department of Labor Hygiene and Environmental Health, School of Public Health, Capital Medical University, Beijing 100071, China.
Publication Type:Specialcolumn:Healthhazardsofdieselexhaustexposure
Keywords: diesel engine exhaust; epigenetics; DNA methylation; non-coding RNA
From: Journal of Environmental and Occupational Medicine 2023;40(5):520-523
CountryChina
Language:Chinese
Abstract: Diesel exhaust (DE) can enter the organism body and cause multiple organ damage. DE contains particles that can be suspended in the air for a long time. Epigenetic regulation is a post transcriptional regulation change that does not involve DNA sequence changes. Many evidences showed that DE can affect the normal physiological functions of multiple organs and systems through epigenetic changes, thus regulating the occurrence and development of multiple diseases. This paper reviewed the research progress of DNA methylation and non-coding RNA in the biological harmful effects of DE. This will provide a basis for the safety evaluation, health risk assessment, and management of DE.