Research progress on the mechanism of valproic acid against glioma
- VernacularTitle:丙戊酸抗胶质瘤的作用机制研究进展
- Author:
Shuxian ZHANG
1
;
Kun ZHU
1
;
Shuangping LIU
1
Author Information
1. School of Medicine，Dalian University，Liaoning Dalian 116622，China
- Publication Type:Journal Article
- Keywords:
valproic acid;
glioma;
cell apoptosis;
histone deacetylase inhibitor
- From:
China Pharmacy
2023;34(10):1276-1280
- CountryChina
- Language:Chinese
-
Abstract:
Gliomas are commonly central nervous system tumors. The conventional treatment is surgical resection combined with chemoradiotherapy， but glioma patients often have a poor prognosis. Therefore， there is an urgent need to identify new potential targets in gliomas and develop more effective treatments. Valproic acid has the properties of histone deacetylase inhibitor， which has been proven to have inhibitory effects on various tumors. It is confirmed that valproic acid could promote apoptosis and cell arrest of glioma cells， inhibit cell invasion and glioma stem cells， increase the sensitivity of glioma cells to radiotherapy and chemotherapy by regulating ERK/Akt signaling pathway， Akt/mTOR signaling pathway， and regulating expression levels of RECK， MGMT， Nrf2， PON2， Smad4， GSK3β and other proteins. In addition， valproic acid can also enhance the effectiveness of anticancer drugs by inhibiting the growth of glioma stem cells and inducing their differentiation. In conclusion， valproic acid can inhibit glioma through multiple targeted actions， and may become a new targeted drug for the treatment of glioma.
