Effects of inhaled budesonide on the expression of nuclear factor-κB and intercellular adhesion molecule-1 in airway epithelial cells of asthma rats
- VernacularTitle:糖皮质激素对哮喘大鼠气道上皮细胞NF-κB、ICAM-1表达的影响
- Author:
Hong-wei WANG
;
Yu-xia SHAO
;
Rui LIANG
- Publication Type:Journal Article
- Keywords:
asthma, airway remodeling, nuclear factor-kappa B(NF-κB), intercellular adhesion molecule(ICAM-1), glucocorticoid
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(1):41-42
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of early inhaled budesonide on the expression of nuclear factor-kappa B(NF-κB) and intercellular adhesion molecule(ICAM-1) in airway epithelial cells of asthma rats.Methods30 rats were randomly divided into three groups:control group, asthma group and therapeutic group with inhaled budesonide.The expression of NF-κB and ICAM-1 in bronchial epithelium were observed with immunohistochemical staining and computer image analysis system.ResultsThe expression of NF-κB, ICAM-1 and subepithelial collagen deposition were significantly highly in asthma group than those of control group and of therapeutic group (P<0.01 respectively). There was a close correlation between the expression of NF-κB and ICAM-1 in asthma rats (r=0.61,P<0.01), as well as between the expression of ICAM-1 and supepithelial collagen(r=0.47,P<0.01).ConclusionThe excessive expression of NF-κB and ICAM-1 play an important role in the pathogenesis of airway remodeling in asthma.Budesonide can influence airway remodeling by downregulating the expression of NF-κB and ICAM-1.
