Effect of behavior training on the expression of NR2B around the infarcted focus and in the cortex of temporal lobe in rats with bilateral hippocampal infarction
- VernacularTitle:行为训练对大鼠海马梗死灶周围及颞叶皮层NR2B表达的影响
- Author:
Hui-juan PAN
;
Ling LI
;
Hua YANG
;
Shan JIANG
;
Yongxia TAN
- Publication Type:Journal Article
- Keywords:
cerebral infarction, hippocampus, N-methyl-D-aspartate (NMDA), receptor(NR2B), rat
- From:
Chinese Journal of Rehabilitation Theory and Practice
2006;12(1):5-7
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the effect of behavior training on the expression of NR2B around the infarcted focus and in the cortex of temporal lobe in rats with bilateral hippocampal infarction.Methods54 SD rats were randomized into pre-training, 7 d, 14 d, 21 d after training groups, pre-immobilization, 7 d, 14 d, 21 d immobilization groups and control group. Behavior training and immobilization were performed on the 3rd day after the infarction. Immunohistochemistry was used to detect the expression of NR2B around the infarcted focus and in the cortex of temporal lobe at different points of time.ResultsThe expression of NR2B was abundant in the normal hippocampus and cortex of temporal lobe of rats. The expression of NR2B decreased after infarction and increased after behavior training. However, the expression of NR2B had little increased in immobilization groups, and showed significant difference compared with that in behavior training groups (P<0.01).ConclusionBehavior training can accelerate the expression of NR2B around the infarcted focus and in the cortex of temporal lobe in rats with bilateral hippocampal infarction.
