Research advances in toxicity of uranium in vivo and its new chelators
10.13491/j.issn.1004-714X.2022.03.023
- VernacularTitle:体内铀毒性及其新型促排剂研究进展
- Author:
Wenhua ZHOU
1
;
Jinjin YING
2
;
Jie GAO
2
;
Huan LIU
2
;
Ruoqi WANG
2
;
Jianguo LI
2
Author Information
1. Shanxi University of Chinese Medicine, Jinzhong 030619 China.
2. China Institute for Radiation Protection, Taiyuan 030000 China.
- Publication Type:ReviewArticles
- Keywords:
Uranium;
Chelator;
Nephrotoxicity;
Bone toxicity;
Detoxification
- From:
Chinese Journal of Radiological Health
2022;31(3):379-385
- CountryChina
- Language:Chinese
-
Abstract:
Uranium is an important radioactive actinide in nature and an important nuclear material in nuclear industry. After uranium is accidentally released into the environment, it enters the body through the respiratory tract, the digestive tract, and other ways, then enters the circulation system through blood, and is finally mainly deposited in the kidney and bone, causing a certain degree of toxicity. Therefore, efficient low-toxicity chelators are an important way to reduce radionuclide pollution, radiation damage, and chemical toxicity. This article reviews uranium deposition and harm, the detoxification mechanism of uranium chelators, and the research advances in uranium chelators and points out the development trend of uranium chelators.
