Influencing factors for micronucleus levels of peripheral blood lymphocytes of medical radiation workers
10.13491/j.issn.1004-714X.2022.03.003
- VernacularTitle:医疗放射工作人员淋巴细胞微核水平影响因素分析
- Author:
Qianqian MENG
1
;
Ruifeng ZHANG
1
;
Zhongxin ZHANG
1
;
Juancong DONG
1
;
Yayi YUAN
1
;
Chao WANG
1
;
Ting ZHANG
1
;
Xuhong DANG
1
Author Information
1. China Institute for Radiation Protection, Taiyuan 030006 China.
- Publication Type:OriginalArticles
- Keywords:
Radiation worker;
Lymphocyte;
Ionizing radiation;
Micronucleus
- From:
Chinese Journal of Radiological Health
2022;31(3):273-278
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the micronucleus levels of peripheral blood lymphocytes of medical radiation workers, and to provide a basis for radiation protection to reduce occupational hazards caused by ionizing radiation. Methods A total of 1072 medical radiation workers were selected into radiation group, and 329 healthy adults who underwent pre-employment occupational physical examination and intended to be radiation workers were selected into control group. The micronucleated lymphocyte frequency was determined by whole blood micro-culture. Results There were no significant differences in micronucleated cell frequency and micronucleus frequency between the radiation group and the control group (both P > 0.05). The detection rate of micronucleus abnormalities in the radiation group was significantly higher than that in the control group (P < 0.001). Female radiation workers had significantly higher micronucleated cell frequency, micronucleus frequency, and the detection rate of micronucleus abnormalities than male radiation workers (all P < 0.001). Between different types of work, significant differences were observed in micronucleated cell frequency and micronucleus frequency (both P < 0.05), but not in the detection rate of micronucleus abnormalities (P > 0.05). Radiation workers with different lengths of working showed significant differences in micronucleated cell frequency (P < 0.05), micronucleus frequency (P < 0.05), and the detection rate of micronucleus abnormalities (P < 0.001). Significant differences were observed in micronucleated cell frequency and micronucleus frequency between different age groups (both P < 0.05). The Spearman’s rank correlation analysis showed that micronucleated cell frequency and micronucleus frequency were positively correlated with the age of radiation workers (both P < 0.001). Conclusion The micronucleus frequency of radiation workers was related to the type and length of work, and had a positive correlation with age. Radiation protection should be enhanced for workers engaged in medical radiation for a long period, especially female workers and workers with a long length of service.
