Neurological manifestations of COVID-19: systemic review article
- VernacularTitle:COVID-19 халдварын мэдрэлийн илрэл: системт тойм судалгаа
- Author:
Delgermaa Ts
1
;
Tsagaankhuu G
1
Author Information
1. MNUMS, School of Medicine, Department of Neurology
- Publication Type:Journal Article
- Keywords:
COVID-19;
SARS-CoV-2;
Neurological symptoms;
Angiotensin converting enzyme-2 receptor;
Olfactory nerve
- From:Mongolian Medical Sciences
2020;192(2):10-17
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Acute respiratory viral infection caused by human new coronavirus that was reported in last December
of 2019, is becoming the most serious issue worldwide. During human coronavirus infection, upper and
lower respiratory symptoms are common. However, other systemic symptoms, especially neurological
signs were reported previously. It is further noted that sometimes the neurological manifestations can
precede the typical features like fever and cough and later on typical manifestations develop in these
patients. Purpose: to analyze information of neurological manifestations related to COVID-19 disease
and possible way of affection of nervous system by SARS-CoV-2 virus.
Material and Methods:We searched Medline, PubMed, Central and Google Scholar, Web of Science for related published
articles and case reports, using keywords such as “COVID-19”, “Coronavirus”, “pandemic”, “SARS-CoV-2”, “Neurological manifestations”; “Complications”; “Clinical characteristics”. There were found
and considered few articles of clinical characteristics and case series reports related to COVID-19
with neurological manifestations and complications, also articles of SARS-CoV-2 virus affection to
nervous system.
Results:Neurological manifestations including headache, dizziness, myalgia, confusion, and hyposmia
were observed during COVID-19 in 6-36.4% cases. A few cases with COVID-19 showed more
severe symptoms such as stroke, polyneuropathy, encephalopathy, myelitis and acute necrotizing
encephalitis. SARS-CoV-2 viral infection pathway may be two different ways, namely, a) binding
ACE-2 receptor on capillary endothelium and causing inflammation where then can cross blood-brain
barrier and to emerge brain tissue damage; b) entering via nasal epithelium where the bipolar cells
locate, from there directs to central nervous system to cause neuronal injury through olfactory bulb.
Conclusion: neurological manifestations are relatively common in COVID-19, however, there is lack
of evidence-based study. There may have two possible pathways of SARS-CoV-2 to affect nervous
system, but is required necessary further elaborately study
- Full text:2020-192(2)-10-17.pdf
