Prevalence and risk factors of sleep apnea in patients with Alzheimer's disease
10.3969/j.issn.1006-2483.2023.03.035
- VernacularTitle:阿尔茨海默病患者睡眠呼吸暂停综合征患病率及风险因素分析
- Author:
Zhanghui PENG
1
,
2
,
3
,
4
;
Jun LIU
1
,
2
,
3
,
4
;
Wanping LIU
1
,
2
,
3
,
4
;
Jing KUANG
1
,
2
,
3
,
4
;
Xinglin HE
1
,
2
,
3
,
4
;
Li LIU
1
,
2
,
3
,
4
Author Information
1. Department of Neurology , Guang'
2. an People'
3. s Hospital , Guang'
4. an , Sichuan 638000 , China
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Sleep apnea syndrome;
Prevalence of disease
- From:
Journal of Public Health and Preventive Medicine
2023;34(3):157-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the prevalence and risk factors of sleep apnea syndrome (SAS) in patients with Alzheimer's disease (AD), and to provide theoretical basis for the prevention of SAS in AD patients. Methods A total of 130 AD patients admitted to the Department of Neurology of Guang'an People's Hospital of Sichuan Province from January 2019 to September 2022 were selected and divided into control group (without SAS) and observation group (with SAS) according to whether the patients were complicated with SAS{AHI ≥5 times/h}. Snoring, waking at night, dry mouth in the morning, AHI and SaO2 values were compared between the two groups. Clinical data of AD patients, including age, gender, body mass index (BMI), AD course, tobacco and alcohol history, and neurodegenerative diseases, were collected by self-made questionnaire and consulting the patient's electronic medical record bed. Univariate analysis and logistic regression were used to analyze the independent risk factors for SAS in AD patients. Results Among 130 AD patients, 43 cases (33.08%) of SAS occurred. The proportion of snoring, awakening at night, dry mouth in the morning and AHI value in the observation group were significantly lower than those in the control group (P<0.05). SaO2 value in observation group was significantly lower than that in control group (P<0.05). There were significant differences in age, duration of AD, BMI, smoking history, combined hypertension, neurodegenerative disease, PSQI score and PSQI score between the two groups (P<0.05). Multivariate logistic regression analysis showed that BMI≥28 kg/m2, PSQI score >16 points and CDR score ≥2 points were independent risk factors for SAS in AD patients (P<0.05). Conclusion The incidence of SAS associated with AD is higher, and the main risk factors are BMI≥28 kg/m2, PSQI score >16 and CDR score. Polysomnosis monitoring should be performed regularly to prevent SAS.
