Growth and development status of children with severe β-thalassemia and its correlation with serum HGB and SF levels in Bazhong area
10.3969/j.issn.1006-2483.2023.03.030
- VernacularTitle:巴中地区重型β-TM患儿生长发育情况及与HGB和SF水平的相关性
- Author:
Na LI
1
;
Yingge LI
2
Author Information
1. Laboratory Department of Bazhong Central Hospital , Bazhong , Sichuan 636000 , China
2. Laboratory Department of Luoyang Maternal and Child Health Hospital , Luoyang , Henan 471000 , China
- Publication Type:Journal Article
- Keywords:
β-thalassemia;
Growth and development;
Sex hormone levels;
Serum HGB and SF levels
- From:
Journal of Public Health and Preventive Medicine
2023;34(3):137-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the growth and development status of children with severe β-thalassemia major (β-TM) in Bazhong area and its correlation with hemoglobin concentration (HGB) and serum ferritin (SF) level, and to provide a theoretical basis for the diagnosis and treatment of children with β-TM in Bazhong area. Methods A total of 292 children with β-TM admitted to Bazhong Central Hospital from January 2019 to December 2020 were selected. The Z-score method was used to evaluate the growth and development of the children. According to the growth and development of the children, they were divided into the normal group (normal growth and development, n=163) and delayed group (growth and development delay, n=129). Another 60 healthy children were selected as the control group. The levels of HGB, serum SF, free triiodothyronine (FT3), free tetraiodothyroxine (FT4), and thyroid stimulating hormone (TSH) were compared among the three groups of children, and clinical data such as age, sex and age of onset were collected from the case system. Univariate analysis and logistic regression were used to analyze the independent risk factors of growth and development delay in β-TM children. Pearson correlation was used to analyze the correlation between growth retardation and HGB and serum SF levels in β-TM children. Results The serum SF and TSH levels in the delayed group were significantly higher than those in the normal group and the control group, while the levels of HGB and serum FT4 were significantly lower than those in the normal group and control group (P<0.05). There were significant differences in age of onset, course of disease, age of primary blood transfusion, compliance with iron removal, compliance with blood transfusion treatment, hypothyroidism and abnormal glucose metabolism between the delayed group and the normal group (P<0.05). Logistic regression analysis showed that poor compliance, HGB<90 g/L, and SF>2000 ng/mL were risk factors for growth retardation in β-TM children (P<0.05). Pearson correlation analysis showed that HGB was negatively correlated with HAZ score of β-TM children (r=-0.452 , P<0.05), while SF was positively correlated with growth HAZ score of β-TM children (r=0.412 , P<0.05). Conclusion The children with β-TM in Bazhong area are often accompanied by slow growth and development, which is closely related to HGB and serum SF levels. Especially for children with poor compliance of iron removal therapy, HGB<90 g/L, and SF>2000 ng/mL, the height, weight, and HGB and serum SF levels should be monitored regularly.
