Circulation of enteroviruses among healthy children under 5 years of age and clinical features of infection
- VernacularTitle:5 хүртэлх насны хүүхдийн дундах энтеровирүсийн орчил, өвчлөлийн эмнэлзүйн онцлог
- Author:
Ariuntugs S
1
;
Ankhmaa B
1
;
Tuguldur B
1
;
Altanchimeg S
2
;
Altantsetseg D
2
;
Sarangua G
2
;
Oyunbileg J
1
;
Ichinkhorloo B
1
Author Information
1. National Center for Public Health, Polio Laboratory
2. National Center for Communicable Diseases
- Publication Type:Journal Article
- Keywords:
enteroviruses;
isolation rate;
hand;
foot and mouth disease
- From:Mongolian Medical Sciences
2019;189(3):40-49
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:Major outbreaks of infectious diseases caused by enteroviruses (EV) have been reported in recent
years. As of 2017, in Mongolia, hand, foot and mouth disease, or HFMD, accounts for 13.7% of all infectious diseases. The purpose of this study was to investigate the circulation of EV among healthy children, and clinical characteristics of infection.
Materials and Methods :The analysis of EV circulation was conducted on Polio Laboratory data of 1172 specimens, collected in
2013-2018, from 9 districts of UB and 21 provinces of Mongolia. Also specimens of 239 patients, who
underwent outpatient and inpatient treatment at the NCCD in 2014-2018, were randomly selected and
stool samples were collected. Clinical symptoms of patients were analyzed and virus isolation analysis
was performed in order to confirm the diagnosis.
Results:Children from 1 month of age to 5 years have participated in the study and the average age was 2 years and 5 months. The enterovirus rate among healthy children was 20.1%. Virus circulation rate was highest in 2013 (37.2%), lowest in 2014 (11.8%). The peak of circulation is observed in May and October, while the minimum rate is in July.
Out of selected patients 52.7% (n=126) were diagnosed with HFMD, rash infection occurred in 28.5%
(n=68), acute flaccid paralysis-18.8% (n=45). EV was detected in 56.4% (n=135) of the collected stool
samples.
Children from 1 month of age to 5 years have participated in the study and the average age was 2 years and 5 months (95% CI:2.5 ±0.1). 49% (n=578) of participants were female, 50.7% (n=594) were male. The enterovirus rate among healthy children were 20.1% (n=236; 95% CI: 20.1 ± 0.55). Virus circulation rate was highest in 2013 (37.2%), lowest in 2014 (11.8%). The peak of circulation is observed in May and October, while the minimum rate is in July. Although the enterovirus isolation rate was relatively high among children under 3, there was no statistically significant difference (p>0.05), as well as there was no difference in gender (p>0.05). As for the EV circulation by region, the highest prevalence rate is found in Central region (27.5%), while the lowest is in the Eastern region (12.7%) with no statistical significance by regions (p>0.05).
Conclusions:Among children, HFMD is a common disease, that caused by EV. Enterovirus infection can often cause
fever, flu like symptoms as well as spotted, maculopapular rash. The EV isolation rate of 20.1% indicates
that the incidence of enterovirus is characterized by symptoms of influenza-like illness or is asymptomatic.
- Full text:2019-189(3)-40-49.pdf
