Role of Histone Modifications and 12/15-lipoxygenase Metabolic Pathway in the Development of Diabetic Kidney Disease
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0323
- VernacularTitle:组蛋白化学修饰与12/15－脂氧化酶代谢途径在糖尿病肾病发展中的作用
- Author:
Jing LUO
1
;
Hang YUAN
1
Author Information
1. Department of Nephrology， The First Hospital of Jilin University， Changchun 130021， China
- Publication Type:Review
- Keywords:
diabetic kidney disease （DKD）;
12/15-lipoxygenase （12/15-LO）;
histone chemical modifications;
metabolic memory;
TGF-β
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(3):534-540
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD） is one of the most common microvascular complications in patients with diabetes. DKD is also the main cause of end-stage renal failure， with very complex pathogenesis. A large number of experiments have confirmed that epigenetic mechanisms， including histone chemical modifications and lipid metabolites 12/15-lipoxygenase （12/15-LO）， are involved in regulating the characteristic pathophysiological process of DKD， based on which， this review further explores the pathogenesis of DKD and provides the new research direction for DKD treatment.
