Immune-related Features of Esophageal Squamous Cell Carcinoma：A Multi-omics Perspective
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0321
- VernacularTitle:从多组学角度探讨食管鳞状细胞癌的免疫相关特征
- Author:
Shao-yi ZHENG
1
;
Yi-yan LEI
1
Author Information
1. Department of Thoracic Surgery， The First Affiliated Hospital， Sun Yat-Sen University， Guangzhou 510062， China
- Publication Type:Review
- Keywords:
esophageal squamous cell carcinoma;
immune features;
immunotherapy;
multi-omics analysis;
literature review
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(3):519-527
- CountryChina
- Language:Chinese
-
Abstract:
Esophageal squamous cell carcinoma is a common malignancy in the Asia-Pacific region， especially in China， where the morbidity remains high in spite of the improved overall survival due to advances in medical technology. Immunotherapy becomes a hot spot in recent tumor research when it has provided significant survival benefits in patients with advanced malignant tumors， such as lung cancer， breast cancer， colon cancer， etc. In esophageal squamous cell carcinoma， immunotherapy promotes survival benefit as well. However， because of the complex and changeable biological functions and gene expression regulation of malignant tumors， the conclusions based on a single-omics analysis are often incomprehensive. Currently， most of the immune-related studies on esophageal squamous cell carcinoma are still confined to a single-omics study like genomics， with limitations and one-sidedness. Since multi-omics analysis helps us better understand tumors from a wider and deeper perspective， this review explores and summarizes immune-related features of esophageal squamous cell carcinoma from a multi-omics perspective.
