Research Progress of NK Cells in Immunotherapy of Glioma
10.13471/j.cnki.j.sun.yat-sen.univ（med.sci）.2023.0320
- VernacularTitle:自然杀伤细胞在神经胶质瘤免疫治疗中的研究进展
- Author:
Shi-long SUN
1
;
Bao-dong CHEN
1
Author Information
1. Department of Neurosurgery， Peking University Shenzhen Hospital， Shenzhen 518036， China
- Publication Type:Review
- Keywords:
glioma;
natural killer cell;
immunotherapy;
clinical trial
- From:
Journal of Sun Yat-sen University(Medical Sciences)
2023;44(3):511-518
- CountryChina
- Language:Chinese
-
Abstract:
Natural Killer （NK） cells are another type of anti-tumor immune cells with promising clinical application in addition to T cells. NK cell activity is mainly regulated by its surface receptors and immune microenvironment. The strong immunosuppressive microenvironment of glioma results in low efficiency of NK cell immunotherapy. This article reviews NK cells in the immunotherapy for glioma from the interaction of glioma-NK cell， and the latest research progress of targeted NK cells compounds， monoclonal antibody， and cytokine therapy， focusing on the genetic modification of NK cells in the present situation and trend of glioma immunotherapy， and molecular mechanism of glioma cells related to immune escape. We hope this article will provide theoretical basis and new ideas for NK cell-based immunotherapy of glioma.
