Research advances in acute pancreatitis-associated ascites fluid
10.3969/j.issn.1001-5256.2023.05.035
- VernacularTitle:急性胰腺炎相关腹腔积液的研究进展
- Author:
Zhangpeng WANG
1
,
2
;
Jun WU
1
,
3
;
Guangxu JING
1
,
2
;
Xuyang WANG
1
,
4
;
Hong ZOU
1
;
Hongyu SUN
1
,
5
;
Lijun TANG
1
,
2
Author Information
1. PLA Center of General Surgery/Key Laboratory of Pancreatic Injury and Repair of Sichuan Province, The General Hospital of Western Theater Command, Chengdu 610083, China
2. College of Medicine, Southwest Medical University, Luzhou, Sichuan 646000, China
3. College of Medicine, Southwest Jiaotong University, Chengdu 610063, China
4. College of Medicine, Chongqing Medical University, Chongqing 400016, China
5. Basic Medical Laboratory, The General Hospital of Western Theater Command, Chengdu 610083, China
- Publication Type:Review
- Keywords:
Pancreatitis;
Ascites Fluid;
Pathologic Processes
- From:
Journal of Clinical Hepatology
2023;39(5):1227-1233
- CountryChina
- Language:Chinese
-
Abstract:
Acute pancreatitis-associated ascites fluid (PAAF) is a common complication in patients with acute pancreatitis (AP) and is closely associated with the severity of AP, the development of local and systemic complications, and prognosis. PAAF may originate from the leakage of abdominal blood vessels, lymphatic vessels, and pancreatic duct. Recent studies have found that early removal of PAAF by abdominal paracentesis drainage can help to reduce systemic inflammation and alleviate pancreatitis-associated organ injury, thereby improving the conditions of patients with severe AP and reducing mortality. However, it is still not completely clear how PAAF aggravates systemic inflammatory response, participates in pancreatic injury and damage of distal organs, and leads to the aggravation of disease conditions in patients with AP. Therefore, this article gives an overview of PAAF and summarizes related studies in recent years, so as to provide directions for exploring the pathophysiological process and treatment of AP.
