Research advances in tumor-associated macrophages in hepatocellular carcinoma microenvironment
10.3969/j.issn.1001-5256.2023.05.033
- VernacularTitle:肝癌微环境中肿瘤相关巨噬细胞的研究进展
- Author:
Peng WANG
1
;
Jiannan QIU
1
;
Zhongxia WANG
1
;
Junhua WU
2
;
Chunping JIANG
1
Author Information
1. Department of Hepatobiliary Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China
2. Nanjing University Medical School, Nanjing 210093, China
- Publication Type:Review
- Keywords:
Carcinoma, Hepatocellular;
Tumor Microenvironment;
Tumor-Associated Macrophages;
Molecular Targeted Therapy
- From:
Journal of Clinical Hepatology
2023;39(5):1212-1218
- CountryChina
- Language:Chinese
-
Abstract:
Since there is a lack of obvious clinical symptoms in the early stage of hepatocellular carcinoma (HCC), most patients have progressed to the advanced stage at the time of confirmed diagnosis. There are limited treatment options for HCC patients who miss the opportunity for surgery, so it is of great importance to find new therapeutic targets. Tumor-associated macrophages (TAMs) are a group of macrophages existing in the tumor immune microenvironment and affect the malignant behaviors of HCC cells and the state of immune escape within the tumor. This article introduces the origin and classification of TAM, summarizes the role and mechanism of TAMs in vascular proliferation, invasion and metastasis, formation and maintenance of stemness, and anti-tumor immunity in HCC, and briefly describes the current research advances in therapeutic targets for TAM, and it is pointed out that targeting TAM may be a promising direction for clinical treatment.
