Role of macrophage polarization and its crosstalk with neighboring cells in hepatocellular carcinoma
10.3969/j.issn.1001-5256.2023.05.032
- VernacularTitle:巨噬细胞极化及其与邻近细胞串扰在肝细胞癌中的作用
- Author:
Huiji SU
1
;
Gengjie YAN
1
;
Hanxiao CHEN
1
;
Shaoqun BAN
1
;
Ailing WEI
1
,
2
;
Dewen MAO
2
;
Fuli LONG
2
Author Information
1. Graduate School of Guangxi University of Chinese Medicine, Nanning 530200, China
2. Second Department of Hepatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China
- Publication Type:Review
- Keywords:
Carcinoma, Hepatocellular;
Macrophages;
Immunotherapy
- From:
Journal of Clinical Hepatology
2023;39(5):1204-1211
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation is closely associated with the development of cancer. Tumor-associated macrophages (TAM) actively participate in tumor-related inflammation and promote tumor growth and metastasis, while under certain conditions, TAM also show cytotoxicity and tumor killing activity and thus inhibit the progression of cancer. Crosstalk between TAM and neighboring cells is closely associated with the progression of hepatocellular carcinoma (HCC) and drug resistance during treatment. This article summarizes the role of macrophages in HCC and the crosstalk between macrophages and other cells, so as to provide new strategies for the clinical diagnosis and treatment of HCC.
