Association between bile acids and nonalcoholic fatty liver disease
10.3969/j.issn.1001-5256.2023.05.026
- VernacularTitle:胆汁酸与非酒精性脂肪性肝病的关系
- Author:
Junjun WANG
1
;
Xiaobo CAI
1
;
Lungen LU
1
Author Information
1. Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 200080, China
- Publication Type:Review
- Keywords:
Non-alcoholic Fatty Liver Disease;
Bile Acids and Salts;
Receptors, G-Protein-Coupled;
Farnesoid X Receptor
- From:
Journal of Clinical Hepatology
2023;39(5):1166-1171
- CountryChina
- Language:Chinese
-
Abstract:
With the rapid increase in the prevalence rate of nonalcoholic fatty liver disease (NAFLD), new treatment methods are needed to prevent disease progression to liver fibrosis, liver cirrhosis, and liver cancer. Although great efforts have been made to clarify the pathological mechanisms of NAFLD disease progression, there are still no effective treatment methods at present. Bile acids (BAs) regulate systemic metabolism by activating nuclear receptors and G protein-coupled receptors and have been identified as important signaling molecules involved in lipid, glucose, and energy metabolism. Dysregulation of BA homeostasis is associated with the severity of NAFLD. This article summarizes the important ligands in BA metabolism and their role in the progression of NAFLD, in order to provide a basis for the treatment of NAFLD by targeting BA messengers.
