Epidemiological situation of hepatitis D in the gathering area of Mongolian population in Inner Mongolia Autonomous Region of China
10.3969/j.issn.1001-5256.2023.05.012
- VernacularTitle:内蒙古自治区蒙古族聚集区丁型肝炎流行现状分析
- Author:
Chunshan FU
1
;
Xiaomei FENG
2
;
Xiumei CHI
3
;
Jun ZI
3
;
Junqi NIU
4
;
Zhuancai ZHANG
1
Author Information
1. First Department of Gastroenterology, Inner Mongolia International Mongolian Hospital, Hohhot 010013, China
2. Department of Clinical Laboratory, Inner Mongolia International Mongolian Hospital, Hohhot 010013, China
3. Gene Therapy Laboratory, Center for Pathogen Biology and Infectious Diseases, The First Hospital of Jilin University, Changchun 130061, China
4. Department of Hepatology, Center for Pathogen Biology and Infectious Diseases, The First Hospital of Jilin University, Changchun 130012, China
- Publication Type:Original Article_Viral Hepatitis
- Keywords:
Hepatitis D;
Hepatitis Delta Virus;
Hepatitis B;
Epidemiologic Studies
- From:
Journal of Clinical Hepatology
2023;39(5):1076-1080
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the status and molecular epidemiology of hepatitis D virus (HDV) infection in the gathering area of Mongolian population in Inner Mongolia Autonomous Region of China. Methods A total of 230 patients with positive hepatitis B surface antigen (HBsAg) who attended Inner Mongolia International Mongolian Hospital from April 2019 to October 2020 were enrolled, and according to related information, they were divided into hepatitis B+liver cirrhosis group( n =18) and hepatitis B group( n =212). According to HBsAg quantification with a cut-off value of 250 IU/mL, the patients were divided into HBsAg < 250 IU/mL group( n =104) and HBsAg ≥250 IU/mL group( n =126). ELISA was used to detect HDV antibody, and quantitative real-time PCR was used to measure HDV RNA in patients with positive HDV antibody. Genotyping was performed for HDV RNA-positive samples. The chi-square test was used for comparison of categorical data between two groups. Results The positive rate of HDV antibody was 16.09%, and among the patients with positive HDV antibody, the positive rate of HDV RNA was 91.89%. Among the 18 patients with hepatitis B and liver cirrhosis, the positive rate of HDV antibody was 44.44%, and among the patients with positive HDV antibody, the positive rate of HDV RNA was 100%. There were 104 patients with HBsAg < 250 IU/mL, among whom only 3 patients (2.88%) were positive for hepatitis D antibody, and there were 126 patients with HBsAg ≥250 IU/mL, with a positive rate of HDV antibody of 26.98%. Genotype 1 was observed in all the samples that could be genotyped. Conclusion There is a relatively high infection rate of HDV in Inner Mongolia Autonomous Region, especially in patients with HBsAg ≥250 IU/mL or those with liver cirrhosis. It is necessary to strengthen the detection of hepatitis D in HBsAg-positive patients and perform early diagnosis and treatment to prevent the further progression of hepatitis.
