Seroepidemiological characteristics of hepatitis B virus among hospitalized patients aged 18 years or below in Henan Province of China
10.3969/j.issn.1001-5256.2023.05.009
- VernacularTitle:河南省18岁及以下住院患者HBV血清流行病学特征分析
- Author:
Wei LI
1
;
Yanhong KANG
1
;
Jiangfeng ZHANG
2
;
Hui YIN
1
;
Junping LIU
1
;
Yukui LI
1
;
Yi KANG
1
Author Information
1. Department of Infectious Diseases, Henan Provincial People's Hospital, Zhengzhou 450003, China
2. Department of Clinical Laboratory, Henan Provincial People's Hospital, Zhengzhou 450003, China
- Publication Type:Original Article_Viral Hepatitis
- Keywords:
Hepatitis B Virus;
Biomarkers;
Child
- From:
Journal of Clinical Hepatology
2023;39(5):1056-1060
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the current status of hepatitis B virus (HBV) infection among hospitalized patients aged 1-18 years, as well as the status of immunity after hepatitis B vaccination. Methods Related data were collected from the patients aged 1-18 years who were hospitalized in Henan Provincial People's Hospital from July 2020 to July 2021, including serological markers for hepatitis B (HBsAg, anti-HBs, HBeAg, anti-HBe, and anti-HBc) and hepatitis B vaccination. The epidemiological situation of HBV infection was analyzed, as well as the immune effect after vaccination. The trend chi-square test was used for trend analysis. Results A total of 10 658 hospitalized patients were collected, among whom there were 6 372 male patients (59.79%) and 4 286 female patients (40.21%). In this population, the patients with positive HBsAg accounted for 0.28% (30/10 658), with a relatively high proportion of 0.68% and 0.62%, respectively, in the 17-and 18-year age groups; the patients with positive anti-HBs accounted for 51.82% (5 523/10 658), with a relatively high proportion of > 63% in the 1-4 years age groups, and there was a reduction in the proportion of patients with positive anti-HBs (fluctuating around 40%) in the 5-18 years age groups. With the increase in age, the positive rate of anti-HBs tended to decrease in both male and female patients (male: χ 2 =8.217, P =0.004; female: χ 2 =10.048, P =0.002). Conclusion Based on the data of hospitalized patients, HBV infection in the population aged 1-18 years in Henan Province has the characteristics of low prevalence rate and high immunity, and the reduction in the proportion of patients with positive anti-HBs at more than five years after vaccination should be taken seriously in this region.
