Advances in the study of biomarkers of early uranium-induced kidney injury
- VernacularTitle:铀致肾脏损伤早期生物标志物研究进展
- Author:
Xinhua SHI
1
;
Lianfeng ZHAO
2
;
Yichang DOU
1
;
Xiaona GU
2
;
Jingming ZHAN
2
;
Xiangming XUE
2
Author Information
- Publication Type:Journal Article
- Keywords: Uranium; Kidney injury; Early diagnosis; Biomarkers
- From: Chinese Journal of Radiological Health 2023;32(2):188-192
- CountryChina
- Language:Chinese
- Abstract: With the rapid development of the nuclear industry, the uranium-exposed population is rapidly expanding. Kidney injury is a major health concern for uranium-exposed population because uranium is initially retained in the kidneys and induces chemical toxicity. However, the commonly used clinical markers of kidney injury usually show significant changes in the late stages of such damage, making it difficult to monitor the occupational health of uranium-exposed population. In recent years, a number of biomarkers that can reflect early kidney injury caused by uranium have been identified and investigated by enzyme-linked immunosorbent assay and protein blotting. This article will review the studies in this area, with the aim of providing a basis for the diagnosis and understanding the development and prognosis of uranium-induced kidney injury.
