Protective effects of WR-2721 combined with lentinan and cytokines against radiation damage
10.13491/j.issn.1004-714X.2023.02.013
- VernacularTitle:WR-2721与香菇多糖、细胞因子在抗辐射效应中的联合作用
- Author:
Yuming LIU
1
;
Shuqi JIANG
2
;
Dingwen JIANG
1
;
Ying HE
1
;
Kexian LI
1
;
Dengyong HOU
1
Author Information
1. Naval Characteristic Medical Center, Shanghai 200433 China.
2. Zhejiang Chinese Medicine University, Hangzhou 310053 China.
- Publication Type:Journal Article
- Keywords:
Lentinan;
Synergistic effect;
WR-2721;
Cytokine;
Ionizing radiation
- From:
Chinese Journal of Radiological Health
2023;32(2):156-160
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the synergistic protective effects of WR-2721 combined with lentinan and cytokines against radiation damage in mice, and to provide a new treatment for acute radiation injury. Methods Seventy Institute of Cancer Research mice were divided into seven groups: a control group, a model group, WR-2721 group, Lentinan & cytokine group, WR-2721 & Lentinan group, WR-2721 & cytokine group and WR-2721 & Lentinan & cytokine group. All groups except the control group were irradiated with 60Co γ-rays at a dose rate of 0.8 Gy/min and a cumulative dose of 5.0 Gy. The mice were sacrificed by cervical dislocation 14 d after irradiation to measure their spleen index, thymus index, and serum levels of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-11 (IL-11), and tumor necrosis factor-alpha (TNF-α). Results For the mice treated with WR-2721, lentinan, and cytokines, the spleen index was 7.33 ± 2.84, the thymus index was 1.70 ± 0.30, the serum SOD level was 114.0 ± 8.3, the MDA level was 7.33 ± 1.16, the IL-11 level was 155.8 ± 49.4, and the TNF-α level was 174.0 ± 37.8. All these indicators except the spleen index in the combination group significantly differed from those of the model group (P < 0.05 or 0.01), indicating the combined treatment promoted recovery from radiation damage. Conclusion WR-2721 combined with lentinan and cytokines has significant synergistic protective effects, which is a promising treatment for acute radiation injury.
