Traditional Chinese Medicine Monomers in Treatment of Diabetic Retinopathy by Regulating PI3K/Akt Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20222002
- VernacularTitle:中药单体调控PI3K/Akt信号通路干预糖尿病视网膜病变的研究进展
- Author:
Huiyu JIA
1
;
Zhihai FENG
2
;
Wenshuai FENG
3
;
Hongru ZHOU
2
;
Rui CHENG
1
;
Fengzhe YAN
4
;
Shuqian WANG
1
Author Information
1. Henan University of Chinese Medicine，Zhengzhou 450000，China
2. The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
3. Tianjin University of Traditional Chinese Medicine，Tianjin 301617，China
4. Gansu University of Chinese Medicine，Lanzhou 730101，China
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
phosphatidylinositol-3-kinase （PI3K）/protein kinase B （Akt） signaling pathway;
traditional Chinese medicine （TCM） monomers;
blood-retinal barrier;
neovascularization;
neurodegeneration;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(12):265-273
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes retinopathy （DR） is an important cause that threatens the visual health of adults. There are some treatment methods of western medicine with definite efficacy， such as anti-vascular endothelial growth factor and laser photocoagulation， but they have many adverse reactions such as intraocular infection and visual field damage. Traditional Chinese medicine （TCM） therapies are safe and effective， which can complement western medicine. Phosphatidylinositol3-kinase （PI3K）/protein kinase B （Akt） signaling pathway regulates a range of processes including glucose metabolism， cell proliferation， and cell transcription and apoptosis， which is closely related to the occurrence and development of DR. Numerous studies have shown that TCM monomers can participate in maintaining the integrity of blood-retinal barrier and inhibiting retinal neovascularization and neurodegeneration in many aspects such as inhibiting oxidative stress and alleviating inflammatory reaction by regulating the PI3K/Akt pathway， so as to delay the progress of DR. Therefore， this study reviewed PI3K/Akt pathway and its relationship with DR， as well as the TCM monomers in interfering with DR based on PI3K/Akt pathway to provide some ideas for the prevention and treatment of DR in integrated TCM and western medicine.
