Anti-inflammatory Effect and Mechanism of Artesunate： A Review
10.13422/j.cnki.syfjx.20222004
- VernacularTitle:青蒿琥酯的抗炎作用及机制研究进展
- Author:
Linlin LI
1
;
Huimin ZHANG
2
;
Jian SONG
1
;
Xiao ZHANG
1
;
Zaiyun SUI
2
;
Yu FENG
1
Author Information
1. Shandong University of Traditional Chinese Medicine，Jinan 250355，China
2. Shandong Academy of Chinese Medicine，Jinan 250014，China
- Publication Type:Journal Article
- Keywords:
artesunate;
anti-inflammatory effect;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(12):241-247
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation， the basic pathological process of many diseases， can occur in various tissues and organs of the body and cause many diseases including cancer. So far， there are thousands of anti-inflammatory drugs on the market， but most of these drugs have adverse reactions of gastrointestinal injury， and can even cause greater damage to the body. In recent years， the research on the repurpose of Chinese medicine is in the ascendant， and the innovative research on the specific antimalarial drug artemisinin has attracted extensive attention from scholars in China and abroad. Artesunate is a water-soluble derivative of artemisinin， which has the characteristics of quick effect and low toxicity. In addition to its significant therapeutic effect on malaria， artesunate also has a potential anti-inflammatory effect. In this review， the anti-inflammatory effect and mechanism of artesunate were elaborated in detail by consulting the relevant literature. It was found that artesunate had good anti-inflammatory effects in the respiratory system， liver injury， osteoarthritis， dermatitis， kidney inflammation， colitis， neuroinflammation， and even in novel coronavirus disease 2019 （COVID-19）. It was concluded that artesunate mainly participated in apoptotic signal transduction， mediated immune regulation， and improved oxidative stress to play an anti-inflammatory role by acting on nuclear factor-κB （NF-κB）， nuclear factor E2-related factor 2 （Nrf2）， phosphatidylinositol-3 kinase （PI3K）/protein kinase B （Akt）/mammalian target of rapamycin （mTOR）， Toll-like receptor 4 （TLR4）/myeloid differentiation factor 88 （MyD88）/tumor necrosis factor receptor-associated factor 6 （TRAF6）， high mobility group box 1 （HMGB1）/receptor for advanced glycation endproduct （RAGE）， and other pathways. Through the review of the anti-inflammatory effect and mechanism of artesunate， it is expected to provide a reference for the application of artesunate in inflammation resistance and further development and utilization of artesunate in the future.
