Hematological changes in peripheral blood of patient with covid-19 infection reported in Mongolia
- VernacularTitle:Монгол улсад бүртгэгдсэн ковид-19-ийн халдвартай тохиолдлуудын захын цусны шинжилгээний өөрчлөлт
- Author:
Amgaa B
1
;
Baldauren S
1
;
Oyun-Erdene S
1
;
Enkhjargal O
1
Author Information
1. National Center for Communicable Disease, Clinic-chemical laboratory
- Publication Type:Journal Article
- Keywords:
COVID- infection;
peripheral blood test;
leukocyte;
lymphocyte;
thrombocyte;
neulrophil-lymphocyle ratio
- From:
Health Laboratory
2020;12(2):15-22
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:According to CDC guideline, common changes in patient admitted due to pneumonia caused by COVID-19 are lymphopenia (63%), leukocytosis (24-30%), leukopenia (19-25%). Neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), thrombocyte-lymphocyte ratio (PLR) are important to evaluate prognosis of infectious diseases as well as cancer.
Hematological tests are important for diagnosis, treatment and monitoring of patient with COVID-19. Our study objective was to determine the changes of leukocyte, lymphocyte, thrombocyte, NLR, LMR, and PLR in imported cases of COVID-19 into Mongolia.
Method:The data such as age, gender, and laboratory test of a total of 249 cases who admitted to National Center forCommuncable Diseases (NCCD) from March 11 to July 20, 2020 was collected from information system of clinical laboratory of NCCD. Peripheral blood tests were conducted by XN 550 which is fully automated hematological analizator of Sysmex corporation, Japan. Statistical analysis such as mean, standard deviation, probability range was done by Microsoft Excel SPSS -25 program.
Result:Regarding to gender, 163 (66.5%) were male and 86 (34.5%) were female. Mean age was 26 with range age of 11-80. Statistic analysis on leukocyte (mean 6.38 x 109/L; P <0.000), thrombocyte (mean 283 x 109/L P <0.000), neutrophil (mean 3.33 x 109L; P <0.000), lymphocyte {mean 2.3 x 109/L; P <0.000), NLR (mean 1.6, P <0.000), PLR parameter (mean 141.8 P <0.000> were revealed. Leukopenia (<3.98) were in 17 (6.8%), leukocytosis (>10.0) were in 11 (4.4%) cases. Lymphopenia (<1.18) were in 14 (5.6%), lymphocytosis (>3.74) were in 14 (5.6%) cases. Thrombocytosis (>369) were in 21 (8,4%), thrombocytopenia (<163) were in 4(1.6%) cases. Neutropenia (<1.56) were in 14 (5.6%) neutrophilia (>6.13) were in 15 (6%). The rest 220 (88.3%) cases have been determined no changes. PLR were 141.8 ±88.6, NLR were in 1.29 ±1.26 in 249 cases. Increased NLR and decreased PLR were in 10 (4.0%) and 114 (45.7%); increased PLR and decreased PLR in 31 (12.4%) and 28 (11.2%), respectively.
Discussion:Our result which is leukocytosis in 4.4%, leukopenia in 6.8%, lymphopenia in 5.6% of all imported eases ol"CO\ 1D-W. are similar to other studies. However, percentage of changes were lower than similar studies due to low rate of severe cases. It suggests, further studies clinical stages and severity of the infection need to be conducted.
- Full text:HL-2020-12(2)-15-22.pdf
