Evaluation the renal status of kidney donors in light of biomarcers and eGFR
- VernacularTitle:Бөөрний доноруудын бөөрний үйл ажиллагааг бөөрний биомаркер, тТШХ-аар үнэлэх нь
- Author:
Khulan P
1
;
Narantuguldur D
2
;
Naran G
3
;
Bayan-Undur D
2
;
Ganbold G
2
;
Sarantsetseg G
2
Author Information
1. Grandmed hospital
2. First State Central Hospital
3. MAHL
- Publication Type:Journal Article
- From:
Health Laboratory
2019;10(2):10-19
- CountryMongolia
- Language:Mongolian
-
Abstract:
Purpose:Follow-up examinations in kidney donors is an essential yet necessary process in organ transplantation. In this study, we aimed to evaluate kidney function using biomarkers and biomarker based eGFR in kidney donors within 5 years of organ transplantation.
Materials and method:91 donors enrolled in our study. We measured body weight and blood and urine samples for laboratory tests. eGFR was calculated using 6 estimations.
Result:The mean serum creatinine in participants was 0.81±0.22 mg/dL, cystatin C was 1.11±0.19 mg/dL, urea was 31.44±8.02 mg/L. Systolic hypertension in subjects was 130.0±16.5 mmHg while diastolic hypertension was 78.4±10.8 mmHg. In all donors, 15.9% (n=14) had hematuria, 23.6% (n=21) had proteinuria, 24.7% (n=19) had albuminuria. Body weight, creatinine, cystatin C and urea measurements had gradually increased over the years. The average eGFR was 72.9±17.9 to 112.8±34.0 ml/min/1.73m2 showing 0.15%-35.22% before donation. Follow – up rate was 28.3-59.2% of total donors.Having health insurance and living far from Ulaanbaatar city influenced follow – up rate. Donor registration data should be updated regularly.
Conclusion:
1. Serum creatinine, cystatin C, urea was increasing in living kidney donors. Hypertension and microalbuminuria was greater than other donor study results.
2. eGFR decreased 0.15-35.22% in donor. CKD EPI combined equation was best for donor.
3. Health insurance and living far from Ulaanbaatar city were the influencing follow – up rate. Registration data is missing in 25.5%-82.4% of total donors suggesting enhancement in data collection.
- Full text:HL-2019-10(2)-10-19.pdf
