Research progress of boron-containing drugs
10.11665/j.issn.1000-5048.20221101002
- VernacularTitle:含硼药物的研究进展
- Author:
Fenghua DU
1
;
Zhengchuan DONG
;
Leyuan CHEN
;
Wenbin HOU
;
Yiliang LI
Author Information
1. 天津中医药大学
- Publication Type:Journal Article
- Keywords:
boron-containing compound;
approved drug;
covalent inhibition;
drug target;
clinical trial
- From:
Journal of China Pharmaceutical University
2023;54(2):159-171
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the research on boron-containing drugs, especially boric acid drugs, has been increasing gradually.Boron-containing drugs, which have been a new area of research for pharmaceutical chemists in the development of new drugs, play an increasingly important anti-inflammatory, antibacterial, and anti-tumor role.At present, five boron-containing drugs have been approved, many are under clinical trials, and more are under investigation around the world, which has greatly expanded the application of boron in the research of new drugs.This paper introduces the characteristics of boron, and reviews the indications of representative boron-containing drugs in various research stages, their binding mechanisms with targets, and their progress after entering clinical trials, aiming to provide reference for further research on boron-containing drugs.
