Advances in research on small intestinal injuries caused by nonsteroidal anti-inflammatory drugs and its prevention and treatment
10.11665/j.issn.1000-5048.20220930001
- VernacularTitle:非甾体类抗炎药致小肠损伤及药物防治的研究进展
- Author:
Yuchen LI
1
;
Ziqian PAN
;
Mengxue XIAO
;
Yuanyuan ZHANG
Author Information
1. 中国药科大学中药学院中药药理与中医药学系
- Publication Type:Journal Article
- Keywords:
nonsteroidal anti-inflammatory drugs;
intestinal injury;
drug prevention and treatment
- From:
Journal of China Pharmaceutical University
2023;54(2):150-158
- CountryChina
- Language:Chinese
-
Abstract:
Nonsteroidal anti-inflammatory drugs (NSAIDs) are clinically used with common gastrointestinal adverse reactions, among which NSAIDs-induced small intestinal injuries (NSIs) are manifested in the appearance of jejunum and ileal mucosa erythema, erosion, ulcer, hemorrhage, intestinal wall perforation and obstruction et al..The pathological mechanisms of NSIs are complex, with a lack of effective prevention or treatment methods.This review summarizes the research progress of the pathological mechanisms of NSIs as well as the prevention and treatment of NSIs by misoprostol, mucosal protective agents, antibiotics and probiotics, traditional Chinese medicines and their active ingredients, nutritional supplements and other drugs in the past five years, in order to provide reference and basis for the research and development of new NSIs drugs.
