Multi-centre survey and analysis of individual therapy of antimicrobial agents in children
- VernacularTitle:儿童抗菌药物个体化治疗现状的多中心调查与分析
- Author:
Jun WANG
1
;
Xiaoling WANG
2
;
Yang WANG
1
;
Yan MEI
1
;
Jing PENG
1
;
Maochang LIU
1
;
Hua XU
1
Author Information
1. Dept. of Pharmacy，Wuhan Children’s Hospital，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430016，China
2. Dept. of Pharmacy，Beijing Children’s Hospital，Capital Medical University，National Center for Children’s Health，Beijing 100045，China
- Publication Type:Journal Article
- Keywords:
antimicrobial agents;
child;
individual therapy;
therapeutic drug monitoring
- From:
China Pharmacy
2023;34(9):1131-1136
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the development of individual therapy of antimicrobial agents in pediatric patients. METHODS A questionnaire survey was conducted to investigate the individual therapy of antimicrobial agents in 30 children’s hospitals and pediatric departments of general hospitals in China. The survey data was analyzed statistically by Microsoft Excel 2007 and SPSS 26.0 software. RESULTS In this survey， 75 questionnaires were collected， and 53 of them were valid with an effective rate of 70.7%. The results showed that 86.7% （26/30） of the hospitals carried out individual therapy of antimicrobial agents in different forms. Clinical needs primarily contributed to the individual therapy in these hospitals， while the insufficient personnel and equipment were the biggest obstacles for individual therapy. The proportions of hospitals， who implemented evidence- based pharmacy， therapeutic drug monitoring （TDM）， model-informed precision dosing （MIPD） and antimicrobial-related genetic tests were 70.0%， 80.0%， 30.0% and 33.3%， respectively. Various detection methods of TDM were carried out in various hospitals， and the antimicrobial agents which needed TDM focused on vancomycin and voriconazole. Moreover， nearly half of pharmacists did not know much about MIPD. CONCLUSIONS At present， TDM is the main way to develop individual therapy of antimicrobial agents in various hospitals， but its monitoring coverage and testing standards need to be improved. MIPD and antimicrobial-related gene tests still need to be further promoted in clinical practice.
