Research status on the role of heat shock protein in organ transplantation
10.3969/j.issn.1674-7445.2023.03.019
- VernacularTitle:热休克蛋白在器官移植中的作用研究现状
- Author:
Xuechao CHENG
1
;
Yongxiang SONG
;
Hui MENG
Author Information
1. Department of Cardiothoracic Surgery, the Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai 519100, China
- Publication Type:Research Article
- Keywords:
Heat shock protein;
Organ transplantation;
Lung transplantation;
Heart transplantation;
Liver transplantation;
Kidney transplantation;
Organ protection;
Ischemia-reperfusion injury
- From:
Organ Transplantation
2023;14(3):455-
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation is an effective treatment for multiple end-stage diseases. In recent years, rapid progress has been made in the field of organ transplantation, which has been widely accepted and applied in clinical practice. However, low utilization rate of donors and high postoperative complications remain to be urgently resolved. Heat shock protein (HSP) is a category of protein family induced by heat shock or other stressors. Upon stress stimulation, HSP plays an anti-inflammation, anti-oxidation and anti-apoptosis role in mitigating the stress-induced damage. HSP is also involved in the processes of promoting immune response and anti-rejection, etc. Organ transplantation, as a stress stimulus, could induce HSP to function in the process of organ transplantation through many patterns, thereby alleviating the allograft damage, improving the utilization rate of donors and prolonging the postoperative survival of recipients. In this article, research status on the role of HSP in lung transplantation, heart transplantation, liver transplantation and kidney transplantation were reviewed, aiming to provide reference for donor protection of organ transplantation and treatment of postoperative complications.
