Research progress on cold ischemia injury of steatotic donor livers
10.3969/j.issn.1674-7445.2023.03.018
- VernacularTitle:脂肪变性供肝冷缺血损伤的研究进展
- Author:
Hanwen YANG
1
;
Qiang WANG
;
Ke CHENG
;
Mingxin CAI
;
Yujun ZHAO
Author Information
1. Department of Organ Transplantation, the Third Xiangya Hospital of Central South University, Changsha 410006, China
- Publication Type:Research Article
- Keywords:
Steatotic donor liver;
Cold ischemic injury;
Liver transplantation;
Mitochondria;
Endoplasmic reticulum;
Adenosine monphosphate activated protein kinase (AMPK);
Aldehyde dehydrogenase 2 (ALDH2);
Heme oxygenase (HO)-1
- From:
Organ Transplantation
2023;14(3):449-
- CountryChina
- Language:Chinese
-
Abstract:
Liver transplantation is a vital treatment for end-stage liver disease. However, the shortage of donor livers has limited the development of liver transplantation. How to expand the source of donor livers has become a challenge in the academic community. In recent years, the proportion of donors with non-alcoholic fatty liver disease (NAFLD) has been increased. Rational use of steatotic donor livers is a feasible approach to expand the donor pool. Cold ischemia injury during donor liver preservation before liver transplantation increases the risk of postoperative organ dysfunction. Therefore, it is of significance to unravel the mechanism and intervention measures of cold ischemia injury of steatotic donor livers. Cold ischemia injury of steatotic donor livers is characterized as the damage of mitochondria, lysosomes and endoplasmic reticulum at the organelle level, and up-regulated expression of adenosine monphosphate activated protein kinase (AMPK), aldehyde dehydrogenase 2 (ALDH2) and heme oxygenase (HO)-1 at the protein level. In this article, the research progresses on cold ischemia injury of steatotic donor livers and relevant intervention measures were reviewed.
