Successful treatment of acute leukemia by secondary transplantation after the first haploidentical hematopoietic stem cell transplantation failure
10.3969/j.issn.1674-7445.2023.03.015
- VernacularTitle:二次移植成功治疗急性白血病单倍体造血干细胞移植植入失败
- Author:
Kezhi HUANG
1
;
Yiqing LI
;
Shaofan XIE
;
Jie XIAO
;
Wenjuan YANG
;
Shuangfeng XIE
;
Liping MA
;
Danian NIE
Author Information
1. Department of Hematology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangzhou 510120, China
- Publication Type:Research Article
- Keywords:
Secondary transplantation;
Haploidentical hematopoietic stem cell transplantation;
Transplantation failure;
Acute leukemia;
Thalassemia;
Graft-versus-host disease;
Cyclophosphamide;
Antithymocyte globulin
- From:
Organ Transplantation
2023;14(3):427-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the feasibility of secondary transplantation for patients with acute leukemia after failure of the first haploidentical hematopoietic stem cell transplantation. Methods Two acute leukemia patients underwent the first haploidentical hematopoietic stem cell transplantation from two donors with thalassemia, and the number of collected CD34+ cells was 2.57×106/kg and 1.99×106/kg per donor, respectively. The first haploidentical hematopoietic stem cell transplantation failed. Secondary transplantation was performed from two non-thalassemia donors, and the number of collected CD34+ cells was 4.28×106/kg and 5.75×106/kg per donor, respectively. A reduced-intensity conditioning regimen consisting of fludarabine (Flu), busulfan (Bu) and antithymocyte globulin (ATG) was adopted for the secondary transplantation. Results For two recipients, the time of secondary transplantation of neutrophil and platelet was +12 d and +10 d, +10 d and +10 d, respectively. Up to the final follow-up (+1 062 d and +265 d after secondary transplantation), the primary diseases of both two recipients have been completely relieved without evident post-transplantation complications. Conclusions Secondary transplantation with reduced-intensity conditioning regimen may successfully treat acute leukemia after failure of the first haploidentical hematopoietic stem cell transplantation.
