Effect of donor age on short-term survival of patients with idiopathic pulmonary fibrosis after lung transplantation
10.3969/j.issn.1674-7445.2023.03.014
- VernacularTitle:供者年龄对特发性肺纤维化患者肺移植术后短期生存结局的影响
- Author:
Jing WANG
1
;
Chunlan HU
;
Huizhi YU
;
Xiaoshan LI
;
Bo XU
;
Dongxiao HUANG
;
Chunxiao HU
;
Jingyu CHEN
Author Information
1. Department of Anesthesiology, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China
- Publication Type:Research Article
- Keywords:
Lung transplantation;
Idiopathic pulmonary fibrosis;
Donor age;
Oxygenation index;
Mechanical ventilation;
N-terminal pro brain natriuretic peptide;
Lung allocation score;
Extracorporeal membrane oxygenation
- From:
Organ Transplantation
2023;14(3):420-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of donor age on short-term survival of patients with idiopathic pulmonary fibrosis (IPF) after lung transplantation. Methods Clinical data of 235 IPF donors and recipients of lung transplantation were retrospectively analyzed. Univariate and multivariate Cox proportional hazard regression models were employed to analyze the correlation between donor age and short-term mortality rate of IPF patients after lung transplantation. Kaplan-Meier was used to draw the survival curve. Results Univariate Cox regression analysis showed that donor age was correlated with the 1-year fatality of IPF patients after lung transplantation. The 1-year fatality of recipients after lung transplantation was increased by 0.020 times if donor age was increased by 1 year (P=0.009). Oxygenation index of the donors, preoperative oxygenation index, preoperative lung allocation score, preoperative N-terminal pro brain natriuretic peptide, pattern of transplantation, pattern of intraoperative extracorporeal membrane oxygenation and intraoperative blood transfusion volume of the recipients were correlated with 1-year fatality after lung transplantation (all P < 0.1). Multivariate Cox regression analysis demonstrated that there was no correlation between donor age and 30-, 90-, 180-d and 1-year fatality of IPF patients after lung transplantation (all P > 0.05). Sensitivity analysis showed that there was no significant difference in 30-, 90-, 180-d and 1-year fatality after lung transplantation among donors aged < 18, 18-33, 34-49 and ≥50 years (all P > 0.05). Conclusions Donor age exerts no effect upon short-term survival of IPF patients after lung transplantation. Considering the mechanical ventilation time, oxygenation index, infection and other factors of donors, the age range of lung transplant donors may be expanded.
