Therapeutic strategy for instant blood-mediated inflammatory reaction after islet transplantation
10.3969/j.issn.1674-7445.2023.03.005
- VernacularTitle:胰岛移植即刻经血液介导的炎症反应应对策略
- Author:
Yuwei YANG
1
;
Ting ZHANG
;
Wanli LI
;
Jibing CHEN
;
Hongjun GAO
Author Information
1. Graduate School of Guangxi University of Chinese Medicine, Nanning 530001, China
- Publication Type:Research Article
- Keywords:
Islet transplantation;
Diabetes mellitus;
Instant blood-mediated inflammatory reaction (IBMIR);
Inflammation;
Islet loss;
Islet protection;
Islet encapsulation;
Coagulation
- From:
Organ Transplantation
2023;14(3):352-
- CountryChina
- Language:Chinese
-
Abstract:
As an effective procedure for type 1 diabetes mellitus and end-stage type 2 diabetes mellitus, islet transplantation could enable those patients to obtain proper control of blood glucose levels. Instant blood-mediated inflammatory reaction (IBMIR) is a nonspecific inflammation during early stage after islet transplantation. After IBMIR occurs, coagulation cascade, complement system activation and inflammatory cell aggregation may be immediately provoked, leading to loss of a large quantity of transplant islets, which severely affects clinical efficacy of islet transplantation. How to alleviate the islet damage caused by IBMIR is a hot topic in islet transplantation. Heparin and etanercept, an inhibitor of tumor necrosis factor-α, are recommended as drugs for treating IBMIR following islet transplantation. Recent studies have demonstrated that multiple approaches and drugs may be adopted to mitigate the damage caused by IBMIR to the islets. In this article, the findings in clinical and preclinical researches were reviewed, aiming to provide reference for the management of IBMIR after islet transplantation.
