Current status and reflections on stem cell transplantation in the treatment of testicular aging
10.3969/j.issn.1674-7445.2023.03.001
- VernacularTitle:干细胞移植治疗睾丸衰老的现状与思考
- Author:
Jiahui MO
1
;
Xinyu LI
;
Zhihong CHEN
;
Min ZHANG
;
Chunhua DENG
Author Information
1. Department of Urology and Andrology, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
- Publication Type:Research Article
- Keywords:
Stem cell transplantation;
Testicular aging;
Stem Leydig cell;
Spermatogonial stem cell;
Mesenchymal stem cell;
Induced pluripotent stem cell;
Testosterone
- From:
Organ Transplantation
2023;14(3):319-
- CountryChina
- Language:Chinese
-
Abstract:
Testicular aging is mainly characterized by a gradual decline in the capability of testosterone synthesis and spermatogenesis, which not only affects male fertility, but also correlates with aging-related chronic diseases intimately. Therefore, delaying testicular aging plays a significant role in improving the health and quality of life of middle-aged and elderly men. Stem cells are a cell group with potent self-renewal capability and multi-directional differentiation potential. In recent years, the research of stem cells in basic and clinical application has been carried out in-depth, which has accelerated the development of cell therapy. Currently, stem cell transplantation has been employed to treat multiple diseases, which has captivated widespread attention in the field of aging and regenerative medicine. Stem cell transplantation has demonstrated promising prospects in the treatment of testicular aging. In this article, research profile and progress of stem cell transplantation in the treatment of testicular aging were reviewed, and bottleneck issues encountered in clinical translation and strategies for optimizing clinical efficacy were discussed, aiming to provide novel ideas for the research and development and clinical translation of stem cell therapy for testicular aging.
