Associated factors to lower renal glomerular filtration rate in chronic hepatitis C patients
- VernacularTitle:Хепатит С вирусийн архаг халдвартай өвчтөний бөөрний түүдгэнцэрийн шүүлтийн хурд буурахад нөлөөлөх хүчин зүйлс
- Author:
Gantogtokh D
1
,
2
;
Batbold B
1
;
Burmaajav B
2
Author Information
1. Institute of Medical Sciences
2. Ach Medical University
- Publication Type:Journal Article
- Keywords:
hepatitis C virus infection;
chronic kidney disease;
glomerular filtration rate;
liver cirrohis;
clinical relevance
- From:Mongolian Medical Sciences
2022;201(3):13-19
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction:Studies have shown that hepatitis C virus (HCV) infection not only causes hepatitis, but also pathological changes in other organ systems. Therefore, it is necessary to study the relationship between chronic HCV and chronic kidney disease.
Objective :To determine the factors influencing renal glomerular function in chronic hepatitis C patients
Materials and methods:Patients with chronic hepatitis C virus were referred to Third Central Hospital, Tegsh Huslen Medical Center, two regional 2020 from August to October. Data on morbidity of patients with chronic hepatitis C were analyzed. The results were processed using SPSS-23 software. Statistical probabilities were determined by checking whether there were statistically significant differences between the groups, using logistic regression analysis and chi-square methods.
Results :There were 54 (46.9%) individuals whose renal glomerular filtration rate was reduced to less than 90 ml/min. In a linear regression analysis, a decrease in renal glomerular filtration rate with age was a significant correlation. Renal glomerular filtration rate is decreased in 37% patients by age-related manner (r2 = 0.37). To determine other causes, no significant correlations were observed when grouped by diabetes, cirrhosis, BMI, and hepatic steatosis (p>0.005). The older age of the patient and the high blood pressure were at 6.4 times higher risk to decrease the glomerular filtration rate in patients with chronic hepatitis C (OR 6.4 (95% CI 1.3-31.4), p=0.021) than the patients who have young age and normal blood pressure by multiple logistic regression analysis.
Conclusion:The age of the patient and high blood pressure are contributing factors to the decline in the incidence of low glomerular filtration rate in patients with chronic hepatitis C.
- Full text:2022-201(3)-13-19.pdf
