Platelet-derived Growth Factors and Tissue Repair
- VernacularTitle:血小板源性生长因子与组织修复
- Author:
Guohe YAN
;
Guoping AI
;
Zhongmin ZOU
;
Yongping LI
- Publication Type:Journal Article
- Keywords:
platelet-derived growth factors (PDGFs), tissue repair, gene therapy, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2007;13(1):39-41
- CountryChina
- Language:Chinese
-
Abstract:
Platelet-derived growth factors (PDGFs) are a member of family of glycoprotein dimers (Mr 27000～35000) that exert potent mitogenic and chemotactic activities toward cells of mesenchymal origin. The PDGFs possess a myriad of critical roles in embryonic development,cellular differentiation and response to tissue damage. It is one of the growth factors,which appear early during the process of wound healing. Especially,PDGFs can effectively promote the healing of some chronic refractory wounds,such as diabetes mellitus ulcer,chronic venous ulcer,bedsore,radioactivity ulcer,etc..
