Serum Neopterin Concentration in Children with Graves' Disease.
- Author:
Sung Ho JUNG
;
Moon Young SONG
;
Byung Kyu SHU
;
Byung Churl LEE
- Publication Type:Original Article
- Keywords:
Graves disease;
Neopterin
- MeSH:
Axis, Cervical Vertebra;
Child*;
Graves Disease*;
Humans;
Neopterin*;
Radioimmunoassay;
Thyroid Gland
- From:Journal of Korean Society of Pediatric Endocrinology
1998;3(1):68-72
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE:Neopterin is a marker of activation of the T-lymphocyte/monocyte axis. We measured serum neopterin concentration to investigate whether serum neopterin levels are increased in children with Graves' disease and whether serum neopterin measurement can be used as a marker of disease activity in Graves disease. METHODS:Twenty children with Graves' disease(3 boys and 17 girls) and 15 healthy children(7 boys and 8 girls) are enrolled in this study. Serum neopterin concentrations are measured by radioimmunoassay. RESULTS:Neopterin concentration in children with Graves' disease(1.59+/-1.25ng/ml) is not higher than that of healthy children(1.51+/-0.73ng/ml). Neopterin concentration is not influenced by thyroid function and remission state. CONCLUSION: Serum neopterin level in children with Graves' disease can not be used as a marker of activity.
