Research progress in per- and polyfluoroalkylsubstances （PFASs） exposure and bone health
10.19428/j.cnki.sjpm.2023.22621
- VernacularTitle:全氟化合物暴露对骨健康影响的研究进展
- Author:
Liming XUE
1
;
Wenyuan LU
2
;
Jiale XU
1
;
Yu’e JIN
1
;
Dasheng LU
1
;
Guoquan WANG
1
Author Information
1. Shanghai Municipal Center for Disease Control and Prevention， State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants， Shanghai 200336， China
2. School of Public Health， Shanghai Traditional Chinese Medicine University， Shanghai 201203， China
- Publication Type:Review
- Keywords:
per- and polyfluoroalkyl substance;
bone health;
bone mineral density
- From:
Shanghai Journal of Preventive Medicine
2023;35(4):391-395
- CountryChina
- Language:Chinese
-
Abstract:
Per- and polyfluoroalkyl substances （PFASs） are a new type of persistent organic pollutants with global attention. They have shown multiple toxic effects due to their persistent accumulation in human body through exposure to environmental media such as drinking water， food， atmosphere， and soil. However， the bone toxicity of PFASs has not attracted enough attention. It is believed that the exposure and accumulation of PFASs in human have a significant impact on the bone health， especially hindering the healthy bone development in infants and adolescents， and aggravating the occurrence of bone loss and fracture in the elder populations. This paper will review the research progress of the effects of PFASs exposure on bone health indicators such as bone mineral density， and discuss the mechanisms of PFAS in bone toxicity. This review will provide references for revealing the effects of PFASs exposure on bone health and their toxic mechanisms.
