First isolation of glutinol and a bioactive fraction with good anti-inflammatory activity from n-hexane fraction of Peltophorum africanum leaf
10.1016/j.apjtm.2016.12.004
- Author:
Salmon A. ADEBAYO
1
;
Jacobus N. ELOFF
1
;
Salmon A. ADEBAYO
2
;
Leshweni J. SHAI
2
Author Information
1. Phytomedicine Programme, Department of Paraclinical Sciences, University of Pretoria
2. Department of Biomedical Sciences, Faculty of Science, Tshwane University of Technology
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory;
COX-1/COX-2;
iNOS;
Nitric oxide;
Peltophorum africanum
- From:
Asian Pacific Journal of Tropical Medicine
2017;10(1):42-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-inflammatory activity of different fractions and glutinol (isolated compound), using nitric oxide synthase and cyclooxygenase (COX) inhibition as an indication of anti-inflammatory activity. Methods Anti-inflammatory activity was evaluated using an in vitro assay determining the inhibition of the activity of pro-inflammatory enzyme model. Cyclooxygenases and inducible nitric oxide synthase are crucial enzymes involved in the pathogenesis of many chronic inflammatory conditions. Results Sub-fraction F3.3 that was derived from n-hexane fraction of PA leaves significantly inhibited (P = 0.01) the catalytic activity of COX-2 (IC
