Neuroprotective effect of Spilanthes acmella Murr. on pesticide-induced neuronal cells death
10.1016/j.apjtm.2016.11.012
- Author:
Wilasinee SUWANJANG
1
;
Bongkot KHONGNIAM
1
;
Sujittra SRISUNG
2
;
Supaluk PRACHAYASITTIKUL
3
;
Virapong PRACHAYASITTIKUL
4
Author Information
1. Center for Research and Innovation, Faculty of Medical Technology, Mahidol University
2. Department of Chemistry, Faculty of Science, Srinakharinwirot University
3. Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University
4. Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University
- Publication Type:Journal Article
- Keywords:
Calpain;
Calpastatin;
Neuronal cell;
Pesticide;
Pirimicarb;
Spilanthes acmella Murr.
- From:
Asian Pacific Journal of Tropical Medicine
2017;10(1):35-41
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate protective effects of Spilanthes acmella (S. acmella) Murr. extracts against pesticide-induced neuronal cells death and to elucidate the underlying molecular mechanism in dopaminergic (SH-SY5Y) cells lines. Methods Cell viability of SH-SY5Y cells was studied by treating the cells with various concentration of pirimicarb for 24 h. Neuroprotective effect of S. acmella Murr. extracts was investigated by adding the plant extracts to the medium for 24 h prior to the incubation with 100 μM H
