Lipase inhibitory activity of Lagenaria siceraria fruit as a strategy to treat obesity
10.1016/j.apjtm.2017.03.010
- Author:
Maria MAQSOOD
1
;
Dildar AHMED
1
;
Iqra ATIQUE
1
;
Wajeeha MALIK
1
Author Information
1. Department of Chemistry, Forman Christian College (A Chartered University)
- Publication Type:Journal Article
- Keywords:
Bottle gourd;
Lagenaria siceraria;
Lipase inhibitory activity;
Obesity
- From:
Asian Pacific Journal of Tropical Medicine
2017;10(3):305-310
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore pancreatic lipase inhibitory activity under different extraction conditions in order to track the most potent extract. Methods The methanolic extract and its fractions in solvents of increasing polarity, ether, chloroform, ethyl acetate, n-butanol and water, were made through cold maceration. Extracts in ethanol, ethyl acetate, acetone and chloroform were similarly prepared. Aqueous extract was prepared through hot decoction method. A reported method was used to determine lipase inhibitory activity of extracts and fractions over wide ranges of concentrations. Results The extracts and fractions exhibited concentration dependent activity. The IC
