Microsporidiosis in Iran: A systematic review and meta-analysis
10.1016/j.apjtm.2017.03.017
- Author:
Roghayeh GHOYOUNCHI
1
;
Mahmoud MAHAMI-OSKOUEI
1
;
Azim REZAMAND
1
;
Roghayeh GHOYOUNCHI
2
;
Adel SPOTIN
2
;
Mahmoud MAHAMI-OSKOUEI
2
;
Reza BERAHMAT
2
;
Tahereh MIKAEILI-GALEH
2
;
Ehsan AHMADPOUR
3
;
Azim REZAMAND
4
;
Nayyereh AMINISANI
5
;
Morteza GHOJAZADEH
6
Author Information
1. Pediatric Health Research Center, Tabriz University of Medical Sciences
2. Department of Parasitology and Mycology, Faculty of Medicine, Tabriz University of Medical Sciences
3. Immunology Research Center, Tabriz University of Medical Sciences
4. Department of Pediatrics, Faculty of Medicine, Tabriz University of Medical Sciences
5. Department of Statistics and Epidemiology, Faculty of Health Sciences, Tabriz University of Medical Sciences
6. Research Center of Evidence Based Medicine, Tabriz University of Medical Sciences
- Publication Type:Journal Article
- Keywords:
Epidemiology;
Genotypes;
Iran;
Microsporidia;
Microsporidiosis;
Prevalence
- From:
Asian Pacific Journal of Tropical Medicine
2017;10(4):341-350
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine all evidence about Microsporidia infection in vertebrate/invertebrate hosts and Iranian populations distributed in different regions of the country. Methods All published articles up to December 2015, including descriptive and cross-sectional studies related to the prevalence and genotyping of Microsporidia infection in Iran, was considered in this systematic review. The meta-analysis was done using the random-effects model and Stats Direct statistical software. MEGA 5.05 software and maximum likelihood algorithm with Kimura 2-parameter model were used for phylogenetic analysis. Results Of the 1152 investigated studies, 33 eligible studies reported a prevalence of Microsporidia infection in vertebrate and invertebrate hosts. According to this systematic review, the overall prevalence rate of Microsporidia infection in immunocompromised patients in Iran was 8.18%. Furthermore, the overall prevalence rate of Microsporidia infection in immunocompromised patients with chronic diarrhoea, patients with non-diarrhoea, gastroenteritis, and patients with CD4 (<200 cells/μL) was 15.4%, 4.1%, 0.5%, and 12.9% respectively. The highest prevalence rate of human and animal Microsporidia was estimated in Kerman (29%) and Khuzestan (26.5%). The overall prevalence rate of Microsporidia infection in honeybees using the random-effects model was 40%. Furthermore, the highest prevalence rate of nosemosis was described in East Azerbaijan (48.2%). The most Microsporidia isolates from immunocompromised patients and pigeons in Iran belonged to genotypes D (n = 16; 50%) and E (n = 6; 20.6%) of Enterocytozoon bieneusi. Conclusions This study may be the first systematic review and meta-analysis that provides a broad outlook on the prevalence of microsporidiosis in Iran. It is necessary to investigate Microsporidia infection in vertebrate and invertebrate hosts and environmental resources in Iran.
