Xanthine oxidase inhibitors from Archidendron clypearia (Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants
10.1016/j.apjtm.2017.06.002
- Author:
Nguyen Thuy DUONG
1
;
Pham Duc VINH
1
;
Nguyen Hoang ANH
1
;
Phuong Thien THUONG
2
;
Nguyen Thi HOAI
3
;
Le Nguyen THANH
4
;
Tran The BACH
5
;
Nguyen Hai NAM
6
Author Information
1. Department of Pharmacology, Hanoi University of Pharmacy
2. Department of Pharmaceutical Analysis and Standardization, National Institute of Medicinal Materials
3. Department of Pharmacognosy, Hue University of Medicine and Pharmacy
4. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
5. Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology
6. Department of Medicinal Chemistry, Hanoi University of Pharmacy
- Publication Type:Journal Article
- Keywords:
Inhibitor;
Medicinal plants;
Vietnam;
Xanthine oxidase
- From:
Asian Pacific Journal of Tropical Medicine
2017;10(6):549-556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To screen Vietnamese medicinal plants for xanthine oxidase (XO) inhibitory activity and to isolate XO inhibitor(s) from the most active plant. Methods The plants materials were extracted by methanol. The active plant materials were fractionated using different organic solvents, including n-hexane, ethyl acetate, and n-butanol. Bioassay-guided fractionation and column chromatography were used to isolate compounds. The compounds structures were elucidated by analysis of spectroscopic data, including IR, MS, and NMR. Results Three hundreds and eleven methanol extracts (CME) belonging to 301 Vietnamese herbs were screened for XO inhibitory activity. Among these plants, 57 extracts displayed XO inhibitory activity at 100 μg/mL with inhibition rates of over 50%. The extracts of Archidendron clypearia (A. clypearia), Smilax poilanei, Linociera ramiflora and Passiflora foetida exhibited the greatest potency with IC
