Medicinal plant products targeting quorum sensing for combating bacterial infections
10.1016/j.apjtm.2017.07.021
- Author:
Abdelhakim BOUYAHYA
1
;
Nadia DAKKA
1
;
Abdeslam ET-TOUYS
1
;
Youssef BAKRI
1
;
Abdelhakim BOUYAHYA
2
;
Jamal ABRINI
2
Author Information
1. Laboratory of Human Pathologies Biology, Department of Biology, Faculty of Sciences, Genomic Center of Human Pathologies, Mohammed V University
2. Biology and Health Laboratory, Department of Biology, Faculty of Science, Abdelmalek Essaadi University
- Publication Type:Journal Article
- Keywords:
Bacterial resistance;
Biofilms;
Natural compounds;
Quorum sensing
- From:
Asian Pacific Journal of Tropical Medicine
2017;10(8):729-743
- CountryChina
- Language:Chinese
-
Abstract:
Traditional treatment of infectious diseases is based on compounds that aim to kill or inhibit bacterial growth. The bacterial resistance against antibiotics is a serious issue for public health. Today, new therapeutic targets other than the bacterial wall were deciphered. Quorum sensing or bacterial pheromones are molecules called auto-inducer secreted by bacteria to regulate some functions such as antibiotic resistance and biofilms formation. This therapeutic target is well-studied worldwide, nevertheless the scientific data are not updated and only recent researches started to look into its potential as a target to fight against infectious diseases. A major concern with this approach is the frequently observed development of resistance to antimicrobial compounds. Therefore, this paper aims to provide a current overview of the quorum sensing system in bacteria by revealing their implication in biofilms formation and the development of antibiotic resistance, and an update on their importance as a potential target for natural substances.
