Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis
10.1016/j.apjtm.2017.08.017
- Author:
Sa-Rang OH
1
;
Seon OK
1
;
Tae-Sung JUNG
1
;
Sang-Ok JEON
1
;
Ji-Min PARK
1
;
Ji-wook JUNG
2
;
Deok-Seon RYU
3
Author Information
1. Department of Wellbeing Products Co., Ltd
2. Department of Herbal Medicinal Pharmacology, College of Herbal Bio-industry, DaeguHaany University
3. Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University
- Publication Type:Journal Article
- Keywords:
Angelica gigas Nakai;
Anti-inflammatory effects;
Cytokine;
Dextran sulfate sodium;
Ulcerative colitis
- From:
Asian Pacific Journal of Tropical Medicine
2017;10(9):864-870
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-inflammatory effects of decursin and decursinol angelate-rich Angelica gigas Nakai (AGNE) on dextran sulfate sodium (DSS)-induced murine ulcerative colitis (UC). Methods The therapeutic effect of an AGNE was analyzed in a mouse model of UC induced by DSS. Disease activity index values were measured by clinical signs such as a weight loss, stool consistency, rectal bleeding and colon length. A histological analysis was performed using hematoxylin and eosin staining. Key inflammatory cytokines and mediators including IL-6, TNF-α PGE
