Pharmacological evaluation of smooth muscle relaxant and cardiac-modulation potential of Phyla nodiflora in ex-vivo and in-vivo experiments
10.1016/j.apjtm.2017.10.021
- Author:
Hafiz Muhammad ABDUR RAHMAN
1
;
Khaled AHMED
1
;
Muhammad Fawad RASOOL
1
;
Imran IMRAN
1
Author Information
1. Faculty of Pharmacy, Bahauddin Zakariya University
- Publication Type:Journal Article
- Keywords:
Antiasthmatic;
Antidiarrheal;
Calcium channel blocking activity;
Hypotensive;
Phyla nodiflora
- From:
Asian Pacific Journal of Tropical Medicine
2017;10(12):1146-1153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacological basis of its uses of Phyla nodiflora (P. nodiflora) for the treatment of anomalies predominantly by smooth muscle containing tissues such as gastrointestinal/vascular/broncho spasm and cardiovascular modulation. Methods The crude hydroalcoholic extract of P. nodiflora (Pn.Cr) and its fractions were evaluated on isolated rabbit jejunum, rat trachea, aorta and atrium. To access the contractile or relaxant effects of testing materials, the tissues were mounted in isolated organ bath and responses were recorded with transducers coupled with data acquisition system. BALB/c mice were challenged with castor oil for the assessment of in-vivo antidiarrheal activity. Normotensive rats were used for in-vivo hypotensive study. Results Hydroalcoholic extract of Pn.Cr at variable concentrations inhibited the natural spontaneous rhythm and 80 mmol/L K
