Effects of aqueous extract of Notobasis syriaca on lipopolysaccharide-induced inflammation in rats

Abdullatif AZAB; Abdullatif AZAB; Ahmad NASSAR; Jacob KAPLANSKI; Reem MAHAJNEH; Galila AGAM; Abed N AZAB; Abed N AZAB; Abdullatif AZAB; Abed N AZAB

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Effects of aqueous extract of Notobasis syriaca on lipopolysaccharide-induced inflammation in rats

Author: Abdullatif AZAB ¹ ; Abdullatif AZAB ² ; Ahmad NASSAR ³ ; Jacob KAPLANSKI ³ ; Reem MAHAJNEH ³ ; Galila AGAM ³ ; Abed N. AZAB ³ ; Abed N. AZAB ⁴ ; Abdullatif AZAB ¹ ; Abed N. AZAB ⁵
Author Information

1. Triangle Research and Development Center
2. Institute of applied Research
3. Department of Clinical Biochemistry and Pharmacology, Faculty of Health Sciences, Ben-Gurion University of the Negev
4. Department of Nursing, Faculty of Health Sciences, Ben-Gurion University of the Negev
5. School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev
Publication Type:Journal Article
Keywords: Bacterial endotoxin; Brain; Cytokines; Hypothermia; Natural products; Plants
From: Asian Pacific Journal of Tropical Medicine 2018;11(1):48-52
CountryChina
Language:Chinese
Abstract: Objective: To investigate the effects of a dry aqueous extract of Notobasis syriaca (N. syriaca) on lipopolysaccharide (LPS)-induced inflammation in rats. Methods: Rats were fed the dried extract [500 mg/(kg•d)] for three consecutive days and then were intraperitoneally injected with LPS (1 mg/kg). Two hours after LPS injection, rats were sacrificed and blood and brain regions were collected. Inflammatory mediators' levels in plasma and homogenates of brain regions were determined by ELISA. Results: Pretreatment with the N. syriaca extract resulted in significant anti-inflammatory effects (P<0.05), including: i) attenuated LPS-induced hypothermia; ii) decreased hypothalamus and hippocampus prostaglandin E2 levels in the LPStreated rats; and, iii) reduced hypothalamus and hippocampus interleukin-6 and tumor necrosis factor-levels in the LPS-treated rats. Conclusions: These results suggest that N. syriaca possesses anti-inflammatory properties. Thus, it is possible that long-term consumption of this plant may result in beneficial pharmacological effects.